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Proteina 57- KDa

Mesajde akmm » 13 Dec 2011, 13:41

,,Masaki Kamakura1
1Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan

The honeybee (Apis mellifera) forms two female castes: the queen and the worker. This dimorphism depends not on
genetic differences, but on ingestion of royal jelly, although the mechanism through which royal jelly regulates caste
differentiation has long remained unknown. Here I show that a 57-kDa protein in royal jelly, previously designated as
royalactin, induces the differentiation of honeybee larvae into queens. Royalactin increased body size and ovary
development and shortened developmental time in honeybees. Surprisingly, it also showed similar effects in the
fruitfly (Drosophila melanogaster). Mechanistic studies revealed that royalactin activated p70 S6 kinase, which was
responsible for the increase of body size, increased the activity of mitogen-activated protein kinase, which was involved
in the decreased developmental time, and increased the titre of juvenile hormone, an essential hormone for ovary
development. Knockdown of epidermal growth factor receptor (Egfr) expression in the fat body of honeybees and
fruitflies resulted in a defect of all phenotypes induced by royalactin, showing that Egfr mediates these actions. These
findings indicate that a specific factor in royal jelly, royalactin, drives queen development through an Egfr-mediated
signalling pathway''

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Fac un rezumat iar textul il pastrez ca atare.
Cercetatorul japonez Masaki Kamakura a efectuat un studiu ( http://www.dbbe.fcen.uba.ar/new/conteni ... actin1.pdf )asupra laptisorului de matca.
El spune:Albina mellifera are doua caste femele: matca si lucratoarea.Acest dimorfism tine nu de diferenta genetica ci de consumul de la laptisor de matca; mecanismul in sine care face diferentierea era necunoscut.
Arat aici ca proteina 57-kDa este cea care are rolul de a activa formarea matcii......
Este surprinzator ca aceasta proteina administrata musculitei de otet, Drosophila melanogaster a avut acelasi efect.
Proteina activeaza un lant de transformari.Foarte interesant.Studiul este amplu si merita tradus de cei din domeniul cercetarii.Parerea mea.
Rezist la orice, în afara tentaţiilor.Oscar Wilde
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Proteina 57- KDa

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